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Varicella zoster virus encodes a viral decoy RHIM to inhibit cell death

10 Jul 2020

Abstract excerpt

Herpesviruses are known to encode a number of inhibitors of host cell death, including RIP Homotypic Interaction Motif (RHIM)-containing proteins. Varicella zoster virus (VZV) is a member of the alphaherpesvirus subfamily and is responsible for causing chickenpox and shingles. We have identified a novel viral RHIM in the VZV capsid triplex protein, open reading frame (ORF) 20, that acts as a host cell death...

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PMID: 32649716
DOI: 10.1371/journal.ppat.1008473

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