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Article

Identification of polymorphisms in ultraconserved elements associated with clinical outcomes in locally advanced colorectal adenocarcinoma.

Cancer - 15 Dec 2012

Lin Moubin, Eng Cathy, Hawk Ernest T, Huang Maosheng, Lin Jie, Gu Jian, Ellis Lee M, Wu Xifeng

Abstract excerpt

BACKGROUND: Ultraconserved elements (UCEs) are noncoding genomic sequences that completely identical among human, mouse, and rat species and harbor critical biologic functions. The authors hypothesized that single nucleotide polymorphisms (SNPs) within UCEs are associated with clinical outcomes in patients with colorectal cancer (CRC). METHODS: Forty-eight SNPs within UCEs were genotyped in 662 patients with...

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Identifiers

PMID: 22673945
DOI: 10.1002/cncr.27653
PMCID: PMC3465518

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