Article
SNPs in ultraconserved elements and familial breast cancer risk.
Carcinogenesis - 1 Feb 2008
Yang Rongxi, Frank Bernd, Hemminki Kari, Bartram Claus R, Wappenschmidt Barbara, Sutter Christian, Kiechle Marion, Bugert Peter, Schmutzler Rita K, Arnold Norbert, Weber Bernhard H F, Niederacher Dieter, Meindl Alfons, Burwinkel Barbara
Abstract excerpt
Ultraconserved elements (UCEs) are segments of >200 bp length showing absolute sequence identity between orthologous regions of human, rat and mouse genomes. The selection factors acting on these UCEs are still unknown. Recent studies have shown that UCEs function as long-range enhancers of flanking genes or are involved in splicing when overlapping with exons. The depletion of UCEs among copy number variation as...
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