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Article

Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction.

Kidney international - 1 Sept 2012

Summers Shaun A, Gan Poh-Yi, Dewage Lakshi, Ma Frank T, Ooi Joshua D, O'Sullivan Kim M, Nikolic-Paterson David J, Kitching A Richard, Holdsworth Stephen R

Abstract excerpt

Progressive renal fibrosis is the final common pathway leading to renal failure irrespective of the initiating cause. Clinical studies of renal fibrosis found that prominent mast cell accumulation correlated with worse outcomes. Mast cells are pluripotent innate immune cells that synthesize and secrete profibrotic mediators. Here we use mast cell-deficient (Kit(W-sh/W-sh)) mice to define a functional pathogenic...

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Identifiers

PMID: 22673890
DOI: 10.1038/ki.2012.211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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