Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis.

doi:10.1038/cddis.2016.402

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Article

Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis.

Cell death & disease - 1 Dec 2016

Meng Xiao-Ming, Wang Shuang, Huang Xiao-Ru, Yang Chen, Xiao Jun, Zhang Yang, To Ka-Fai, Nikolic-Paterson David J, Lan Hui-Yao

Abstract excerpt

Myofibroblasts play a central role in renal fibrosis although the origin of these cells remains controversial. We recently reported that bone marrow-derived macrophages can give rise to myofibroblasts through macrophage to myofibroblast transition (MMT). However, several important issues remain to be addressed, including whether MMT occurs in human kidney disease and verification of the MMT process through...

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Identifiers

PMID: 27906172
DOI: 10.1038/cddis.2016.402
PMCID: PMC5261004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.