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ETP-Specific Knockout Mice Reveal Endotrophin as a Key Regulator of Kidney Fibrosis in Ischemia-Reperfusion Injury Models

2025-02-26

Abstract excerpt

<h4>ABSTRACT</h4> Endotrophin (ETP), a cleavage product of the C5 domain of collagen VI α3 (COL6A3), plays a crucial role in extracellular matrix remodeling. Previously established Col6a3 knockout (KO) mouse models primarily reflect the consequences of COL6A3 loss rather than the specific effects of ETP depletion, making it challenging to directly assess ETP’s function. These models either disrupt COL6A3 along w...

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Literature Corpus work
dec8636f-c36f-5549-94f2-3169240d0782
DOI
10.1101/2025.02.20.639288
Open publication

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ETP-Specific Knockout Mice Reveal Endotrophin as a Key Regulator of Kidney Fibrosis in Ischemia-Reperfusion Injury ModelsDOI 10.1101/2025.02.20.639288
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