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Article

[The influence of UPF genes on the severity of SUP45 mutations].

Molekuliarnaia biologiia - 1 Jan 2000

Zhuravleva G A, Gryzina V A

Abstract excerpt

Eukaryotic cells possess special mechanism of the degradation of mRNAs containing premature termination codons (PTCs)--nonsense-mediated mRNA decay (NMD) pathway. In yeast Saccharomyces cerevisiae, the activity of this pathway depends on the recognition of the PTC by the translational machinery and interaction of translation termination factors eRF1 and eRF3 with Upf1, Upf2 and Upf3 proteins. Previously we have...

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Source

Identifiers

PMID: 22670525

Genes

UPF1
UPF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[The influence of UPF genes on the severity of SUP45 mutations].PMID 22670525Read ↗

[SFP1 controls translation termination in Saccharomyces cerevisiae via regulation of the Sup35p (eRF3) level].Semantic proximity Read ↗

Inactivation of NMD increases viability of sup45 nonsense mutants in Saccharomyces cerevisiae.Semantic proximity Read ↗

Viable nonsense mutants for the essential gene SUP45 of Saccharomyces cerevisiae.Semantic proximity Read ↗

The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts.Semantic proximity Read ↗

[Conservation of the MC domains in eukaryotic termination factor eRF3].Semantic proximity Read ↗

[Phenotypic manifestation of epigenetic determinant [ISP+] in Saccharomyces serevisiae depends on combination of mutations in SUP35 and SUP45 genes].Semantic proximity Read ↗

[The influence of mutations at ATG triplets of the open reading frame SUP35 on viability of the yeast Saccharomyces cerevisiae].Semantic proximity Read ↗

Nonsense Mutations in the Yeast SUP35 Gene Affect the [PSI+] Prion Propagation.Semantic proximity Read ↗

Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae.Semantic proximity Read ↗

Overexpression of Upf1p compensates for mitochondrial splicing deficiency independently of its role in mRNA surveillance.Semantic proximity Read ↗

Characterization of the mIF4G domains in the RNA surveillance protein Upf2Semantic proximity Read ↗

N-terminal region of Saccharomyces cerevisiae eRF3 is essential for the functioning of the eRF1/eRF3 complex beyond translation termination.Semantic proximity Read ↗

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