Article
The downregulation of ΔNp63 in p53-deficient mouse epidermal tumors favors metastatic behavior.
Oncotarget - 15 Sept 2015
Bornachea Olga, López-Calderón Fernando F, Dueñas Marta, Segrelles Carmen, Lorz Corina, Suárez-Cabrera Cristian, Marañón María, Paradela-Dobarro Beatriz, Santos Mirentxu, Paramio Jesús M
Abstract excerpt
The TP63 gene codes for two major isoform types, TAp63 and ΔNp63, with probable opposite roles in tumorigenesis. The ΔNp63α protein is frequently amplified and overexpressed in different epithelial tumors. Accordingly, it has been considered a potential oncogene. Nonetheless, a possible metastatic suppressor activity has also been suggested based on the experimental observation that its expression is reduced or...
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