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Article

Inhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged rats.

PloS one - 1 Jan 2012

Sama Diana M, Mohmmad Abdul Hafiz, Furman Jennifer L, Artiushin Irina A, Szymkowski David E, Scheff Stephen W, Norris Christopher M

Abstract excerpt

The role of tumor necrosis factor α (TNF) in neural function has been investigated extensively in several neurodegenerative conditions, but rarely in brain aging, where cognitive and physiologic changes are milder and more variable. Here, we show that protein levels for TNF receptor 1 (TNFR1) are significantly elevated in the hippocampus relative to TNF receptor 2 (TNFR2) in aged (22 months) but not young adult...

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Source

Open in PubMed Open full text

Identifiers

PMID: 22666474
DOI: 10.1371/journal.pone.0038170
PMCID: PMC3362564

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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