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TNFα reduces inhibitory transmission in young <i> Trem2 <sup>R47H</sup> </i> Sporadic Alzheimer rats before observable Aβ and brain pathology

2020-08-20

Abstract excerpt

Trem2 R47H rats, which carry the Alzheimer’s disease (AD) risk factor p.R47H variant of the microglia gene TREM2 and produce human Aβ. Previously, we demonstrated that supraphysiological TNF-α boost glutamatergic transmission and suppresses Long-term-Potentiation (LTP), a surrogate of learning and memory, in peri-adolescent Trem2 R47H rats (Ren et al., 2020). Here we tested the effect of the p.R47H TREM2 vari...

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Literature Corpus work
70315a36-9a60-5d7a-a6b5-812e7a81991d
DOI
10.1101/2020.08.20.256099
Open publication

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