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Article

Role of tumor necrosis factor-alpha in the central nervous system: a focus on autoimmune disorders

7 Jul 2023

Abstract excerpt

Tumor necrosis factor-alpha (TNF-α) is a pleiotropic immune cytokine that belongs to the TNF superfamily of receptor ligands. The cytokine exists as either a transmembrane or a soluble molecule, and targets two distinct receptors, TNF-α receptor 1 (TNFR1) and TNF-α receptor 2 (TNFR2), which activate different signaling cascades and downstream genes. TNF-α cellular responses depend on its molecular form, targeted...

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PMID: 37483590
DOI: 10.3389/fimmu.2023.1213448

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