Article
Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation.
Development (Cambridge, England) - 1 Sept 2021
Peron Margherita, Dinarello Alberto, Meneghetti Giacomo, Martorano Laura, Betto Riccardo M, Facchinello Nicola, Tesoriere Annachiara, Tiso Natascia, Martello Graziano, Argenton Francesco
Abstract excerpt
The STAT3 transcription factor, acting both in the nucleus and mitochondria, maintains embryonic stem cell pluripotency and promotes their proliferation. In this work, using zebrafish, we determined in vivo that mitochondrial STAT3 regulates mtDNA transcription in embryonic and larval stem cell niches and that this activity affects their proliferation rates. As a result, we demonstrated that import of STAT3...
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