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Article

Autophagy‐Sirt3 axis decelerates hematopoietic aging

20 Sept 2020

Abstract excerpt

Autophagy suppresses mitochondrial metabolism to preserve hematopoietic stem cells (HSCs) in mice. However, the mechanism by which autophagy regulates hematopoietic aging, in particular in humans, has largely been unexplored. Here, we demonstrate that reduction of autophagy in both hematopoietic cells and their stem cells is associated with aged hematopoiesis in human population. Mechanistically, autophagy delays...

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PMID: 32951306
DOI: 10.1111/acel.13232

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