Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic susceptibility to a complex disease: the key role of functional redundancy.

History and philosophy of the life sciences - 1 Jan 2011

Debret Gaëlle, Jung Camille, Hugot Jean-Pierre, Pascoe Leigh, Victor Jean-Marc, Lesne Annick

Abstract excerpt

Complex diseases involve both a genetic component and a response to environmental factors or lifestyle changes. Recently, genome-wide association studies (GWAS) have succeeded in identifying hundreds of polymorphisms that are statistically associated with complex diseases. However, the association is usually weak and none of the associated allelic forms is either necessary or sufficient for the disease...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Incidence

Share to Models, Biological

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 22662507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic susceptibility to a complex disease: the key role of functional redundancy.PMID 22662507Read ↗

Network location and clustering of genetic mutations determine chronicity in a stylized model of genetic diseases.Semantic proximity Read ↗

[Complex diseases: the importance of genetics].Semantic proximity Read ↗

Gene-disease network analysis reveals functional modules in mendelian, complex and environmental diseases.Semantic proximity Read ↗

An Expanded View of Complex Traits: From Polygenic to Omnigenic.Semantic proximity Read ↗

The polygenic, omnigenic and stratagenic models of complex disease risk.Semantic proximity Read ↗

Mutation-selection-drift balance models of complex diseases.Semantic proximity Read ↗

Mutation-selection-drift balance models of complex diseasesSemantic proximity Read ↗

Genetic susceptibility to ageing-associated diseases.Semantic proximity Read ↗

Exposure accumulation drives age-dependent disease architectures and polygenic risk scoresSemantic proximity Read ↗

Network Modeling of Crohn's Disease Incidence.Semantic proximity Read ↗

Exposure accumulation drives age-dependent disease architectures and polygenic risk scoresSemantic proximity Read ↗

The mathematical limits of genetic prediction for complex chronic disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.