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Article

The mathematical limits of genetic prediction for complex chronic disease.

Journal of epidemiology and community health - 1 Jun 2015

Keyes Katherine M, Smith George Davey, Koenen Karestan C, Galea Sandro

Abstract excerpt

BACKGROUND: Attempts at predicting individual risk of disease based on common germline genetic variation have largely been disappointing. The present paper formalises why genetic prediction at the individual level is and will continue to have limited utility given the aetiological architecture of most common complex diseases. METHODS: Data were simulated on one million populations with 10 000 individuals in each...

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Identifiers

PMID: 25648993
DOI: 10.1136/jech-2014-204983
PMCID: PMC4430395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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