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Article

EMT and stem cell-like properties associated with HIF-2α are involved in arsenite-induced transformation of human bronchial epithelial cells.

PloS one - 1 Jan 2012

Xu Yuan, Li Yuan, Pang Ying, Ling Min, Shen Lu, Yang Xiaojun, Zhang Jianping, Zhou Jianwei, Wang Xinru, Liu Qizhan

Abstract excerpt

BACKGROUND: Arsenic is well-established as a human carcinogen, but the molecular mechanisms leading to arsenic-induced carcinogenesis are complex and elusive. It is not been determined if the epithelial-mesenchymal transition (EMT) and stem cell-like properties contribute in causing to carcinogen-induced malignant transformation and subsequent tumor formation. METHODS: To investigate the molecular mechanisms...

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Identifiers

PMID: 22662215
DOI: 10.1371/journal.pone.0037765
PMCID: PMC3360629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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