Article
Continuous activation of Nrf2 and its target antioxidant enzymes leads to arsenite-induced malignant transformation of human bronchial epithelial cells.
Toxicology and applied pharmacology - 1 Dec 2015
Yang Xu, Wang Dapeng, Ma Yuan, Xu Xiguo, Zhu Zhen, Wang Xiaojuan, Deng Hanyi, Li Chunchun, Chen Min, Tong Jian, Yamanaka Kenzo, An Yan
Abstract excerpt
Long-term exposure to arsenite leads to human lung cancer, but the underlying mechanisms of carcinogenesis remain obscure. The transcription factor of nuclear factor-erythroid-2 p45-related factor (Nrf2)-mediated antioxidant response represents a critical cellular defense mechanism and protection against various diseases. Paradoxically, emerging data suggest that the constitutive activation of Nrf2 is associated...
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