Article
MicroRNA-191, regulated by HIF-2α, is involved in EMT and acquisition of a stem cell-like phenotype in arsenite-transformed human liver epithelial cells.
Toxicology in vitro : an international journal published in association with BIBRA - 1 Apr 2018
Chen Chao, Yang Qianlei, Wang Dapeng, Luo Fei, Liu Xinlu, Xue Junchao, Yang Ping, Xu Hui, Lu Jiachun, Zhang Aihua, Liu Qizhan
Abstract excerpt
Inorganic arsenic is widely distributed in the environment, and epidemiologic data show a strong association between arsenic exposure and risk of liver cancer. An understanding of the mechanisms underlying development of liver cancer and metastasis would be useful in reducing the incidence and mortality of liver cancer. MicroRNAs (miRs) act as regulators in liver cancer. Here, we show that acute or chronic...
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