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Article

Arsenic exposure transforms human epithelial stem/progenitor cells into a cancer stem-like phenotype.

Environmental health perspectives - 1 Jan 2010

Tokar Erik J, Diwan Bhalchandra A, Waalkes Michael P

Abstract excerpt

BACKGROUND: Inorganic arsenic is a ubiquitous environmental carcinogen affecting millions of people worldwide. Evolving theory predicts that normal stem cells (NSCs) are transformed into cancer stem cells (CSCs) that then drive oncogenesis. In humans, arsenic is carcinogenic in the urogenital sys...

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Identifiers

PMID: 20056578
DOI: 10.1289/ehp.0901059
PMCID: PMC2831952

Genes

ABCG2
PTEN
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20056578-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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