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Article

Arsenic-Specific Stem Cell Selection During Malignant Transformation

25 Mar 2010

Abstract excerpt

BACKGROUND: Arsenic is a carcinogen that targets the urogenital system, including the prostate. Although the mechanisms for arsenic-induced carcinogenesis are undefined, arsenic drives overaccumulation of stem cells and cancer stem cells (CSCs) in vivo and in vitro, indicating that these cells are a key target population. Disruption of stem cell population dynamics may be critical to acquisition of cancer...

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PMID: 20339138
DOI: 10.1093/jnci/djq093

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