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Article

Low dose vaccination with attenuated Francisella tularensis strain SchuS4 mutants protects against tularemia independent of the route of vaccination.

PloS one - 1 Jan 2012

Rockx-Brouwer Dedeke, Chong Audrey, Wehrly Tara D, Child Robert, Crane Deborah D, Celli Jean, Bosio Catharine M

Abstract excerpt

Tularemia, caused by the gram-negative bacterium Francisella tularensis, is a severe, sometimes fatal disease. Interest in tularemia has increased over the last decade due to its history as a biological weapon. In particular, development of novel vaccines directed at protecting against pneumonic tularemia has been an important goal. Previous work has demonstrated that, when delivered at very high inoculums,...

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Identifiers

PMID: 22662210
DOI: 10.1371/journal.pone.0037752
PMCID: PMC3360632

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Low dose vaccination with attenuated Francisella tularensis strain SchuS4 mutants protects against tularemia independent of the route of vaccination.PMID 22662210Read ↗

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