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Article

A Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challenge.

PloS one - 25 Jun 2008

Pechous Roger D, McCarthy Travis R, Mohapatra Nrusingh P, Soni Shilpa, Penoske Renee M, Salzman Nita H, Frank Dara W, Gunn John S, Zahrt Thomas C

Abstract excerpt

BACKGROUND: Francisella tularensis is a gram-negative coccobacillus that causes the febrile illness tularemia. Subspecies that are pathogenic for humans include those comprising the type A (subspecies tularensis) or type B (subspecies holarctica) biovars. An attenuated live vaccine strain (LVS) developed from a type B isolate has previously been used to vaccinate at-risk individuals, but offers limited protection...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18575611
DOI: 10.1371/journal.pone.0002487
PMCID: PMC2429968

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Source receipt: pubmed, retrieved 7 Sept 2026.

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A Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challenge.PMID 18575611Read ↗

Construction and characterization of an attenuated purine auxotroph in a Francisella tularensis live vaccine strain.Semantic proximity Read ↗

Low dose vaccination with attenuated Francisella tularensis strain SchuS4 mutants protects against tularemia independent of the route of vaccination.Semantic proximity Read ↗

Identification of genes contributing to the virulence of Francisella tularensis SCHU S4 in a mouse intradermal infection model.Semantic proximity Read ↗

A mutant of Francisella tularensis strain SCHU S4 lacking the ability to express a 58-kilodalton protein is attenuated for virulence and is an effective live vaccine.Semantic proximity Read ↗

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