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Article

Effects of CYP3A5 genotypes, ABCB1 C3435T and G2677T/A polymorphism on pharmacokinetics of Tacrolimus in Chinese adult liver transplant patients.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Jan 2015

Zhu LiQin, Yang JianWei, Zhang Yuan, Jing YaQing, Zhang YanWen, Li Guang

Abstract excerpt

1. The purpose of this study was to establish a population pharmacokinetic (PK) model of tacrolimus and evaluate the influence of clinical covariates, including the genetic polymorphisms of the cytochrome P450 3A5 gene (CYP3A5) and gene-encoding P-glycoprotein (ABCB1), on the PK parameters in Chinese adult liver transplant recipients. 2. Details of drug dose, sampling times and concentrations were collected...

Read the complete abstract on PubMed

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Source

Identifiers

PMID: 25869250
DOI: 10.3109/00498254.2015.1021733

Genes

CYP3A5
ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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