Article
Partial complementation of the Fanconi anemia defect upon transfection by heterologous DNA. Phenotypic dissociation of chromosomal and cellular hypersensitivity to DNA cross-linking agents.
Human genetics - 1 Dec 1990
Diatloff-Zito C, Rosselli F, Heddle J, Moustacchi E
Abstract excerpt
Transfectants obtained by mouse DNA-mediated gene transfer in Fanconi anemia (FA) primary fibroblasts from the genetic complementation groups A and B were examined for the frequencies of chromosomal aberrations and cytotoxicity following treatments by cross-linking agents. Cells from group A (FA 150), which is the most sensitive to such agents, are partially corrected for both the chromosomal and cellular...
Topics
- Animals
- Cell Line
- Cell Survival
- Chromosome Aberrations
- Cross-Linking Reagents
- DNA
- Drug Resistance
- Fanconi Anemia
- Genetic Complementation Test
- Humans
- Methoxsalen