Article
Functional correction of Fanconi anemia group A hematopoietic cells by retroviral gene transfer.
Blood - 1 Nov 1997
Fu K L, Foe J R, Joenje H, Rao K W, Liu J M, Walsh C E
Abstract excerpt
Fanconi anemia (FA) is an autosomal recessive genetic disorder characterized by a variety of physical anomalies, bone marrow failure, and an increased risk for malignancy. FA cells exhibit chromosomal instability and are hypersensitive to DNA cross-linking agents such as mitomycin C (MMC). FA is a clinically heterogeneous disorder and can be functionally divided into at least five different complementation groups...
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