Cocultivation of Fanconi anemia cells and of mouse lymphoma mutants leads to interspecies complementation of chromosomal hypersensitivity to DNA cross-linking agents.

doi:10.1007/BF00210801

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Article

Cocultivation of Fanconi anemia cells and of mouse lymphoma mutants leads to interspecies complementation of chromosomal hypersensitivity to DNA cross-linking agents.

Human genetics - 1 May 1990

Rosselli F, Moustacchi E

Abstract excerpt

We have studied the effects of cocultivation on the frequency of mitomycin C (MMC)-induced chromosomal aberrations. This was carried out by cocultivating Fanconi anemia (FA) cells from the genetic complementation groups A and B with both normal mouse lymphoma L5178Y cells and the derived "FA-like...

Topics

Anemia, Aplastic
Animals
Cell Division
Cells, Cultured
Chromosome Aberrations
Fanconi Anemia
Genetic Complementation Test
Humans
Lymphoma
Mice
Mitomycin
Mitomycins
Mutation
Tumor Cells, Cultured

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