Cloning of cDNAs for Fanconi's anaemia by functional complementation.

doi:10.1038/356763a0

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Article

Cloning of cDNAs for Fanconi's anaemia by functional complementation.

Nature - 30 Apr 1992

Strathdee C A, Gavish H, Shannon W R, Buchwald M

Abstract excerpt

Fanconi's anaemia is a rare autosomal recessive disorder characterized by progressive pancytopaenia and a cellular hypersensitivity to DNA crosslinking agents. Four genetic complementation groups have been identified so far, and here we use a functional complementation method to clone complementa...

Topics

Amino Acid Sequence
Base Sequence
Blotting, Northern
Cell Line
Cell Survival
Cloning, Molecular
Dose-Response Relationship, Drug
Drug Resistance
Epoxy Compounds
Fanconi Anemia
Gene Library
Genetic Complementation Test
Humans
Mitomycin
Molecular Sequence Data
Mutagens
Mutation
Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 1574115
DOI: 10.1038/356763a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1574115-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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