Article
Cloning of cDNAs for Fanconi's anaemia by functional complementation.
Nature - 30 Apr 1992
Strathdee C A, Gavish H, Shannon W R, Buchwald M
Abstract excerpt
Fanconi's anaemia is a rare autosomal recessive disorder characterized by progressive pancytopaenia and a cellular hypersensitivity to DNA crosslinking agents. Four genetic complementation groups have been identified so far, and here we use a functional complementation method to clone complementary DNAs that correct the defect of group C cells. The cDNAs encode alternatively processed transcripts of a new gene,...
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