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Article

Development and characterization of immortalized fibroblastoid cell lines from an FA(C) mouse model.

Mutation research - 1 Jul 1998

Tomkins D J, Care M, Carreau M, Buchwald M

Abstract excerpt

Fanconi anemia (FA) is an autosomal recessive disorder, characterised by multiple congenital malformations, bone marrow failure and a predisposition to developing malignancies, especially leukemia. FA cells show increased levels of spontaneous chromosomal aberrations and a hypersensitivity to DNA cross-linking agents such as mitomycin C (MMC) and diepoxybutane (DEB). There are at least eight complementation...

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Identifiers

PMID: 9678061
DOI: 10.1016/s0921-8777(98)00015-9

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