Article
Development and characterization of immortalized fibroblastoid cell lines from an FA(C) mouse model.
Mutation research - 1 Jul 1998
Tomkins D J, Care M, Carreau M, Buchwald M
Abstract excerpt
Fanconi anemia (FA) is an autosomal recessive disorder, characterised by multiple congenital malformations, bone marrow failure and a predisposition to developing malignancies, especially leukemia. FA cells show increased levels of spontaneous chromosomal aberrations and a hypersensitivity to DNA...
Topics
- Animals
- Cell Cycle Proteins
- Cell Line, Transformed
- Cell Transformation, Viral
- Chromosome Aberrations
- Cross-Linking Reagents
- DNA-Binding Proteins
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Epoxy Compounds
- Fanconi Anemia
- Fanconi Anemia Complementation Group Proteins
- Fibroblasts
- Mice
- Mice, Knockout
- Mitomycin
- Mutagenicity Tests
- Nuclear Proteins