Article
Saccharomyces cerevisiae 3-methyladenine DNA glycosylase has homology to the AlkA glycosylase of E. coli and is induced in response to DNA alkylation damage.
The EMBO journal - 1 Dec 1990
Chen J, Derfler B, Samson L
Abstract excerpt
We previously cloned a DNA fragment from Saccharomyces cerevisiae that suppressed the alkylation sensitivity of Escherichia coli glycosylase deficient mutants and we showed that it apparently contained a gene for 3-methyl-adenine DNA glycosylase (MAG). Here we establish the identity of the MAG ge...
Topics
- Alkylation
- Amino Acid Sequence
- Base Sequence
- Chromosomes, Fungal
- Cloning, Molecular
- DNA
- DNA Damage
- DNA Glycosylases
- DNA Repair
- Escherichia coli
- Molecular Sequence Data
- Mutation
- N-Glycosyl Hydrolases
- Open Reading Frames
- Protein Biosynthesis
- RNA, Messenger
- Saccharomyces cerevisiae
- Sequence Homology, Nucleic Acid