Article
Biochemical characterization and DNA repair pathway interactions of Mag1-mediated base excision repair in Schizosaccharomyces pombe.
Nucleic acids research - 1 Jan 2005
Alseth Ingrun, Osman Fikret, Korvald Hanne, Tsaneva Irina, Whitby Matthew C, Seeberg Erling, Bjørås Magnar
Abstract excerpt
The Schizosaccharomyces pombe mag1 gene encodes a DNA repair enzyme with sequence similarity to the AlkA family of DNA glycosylases, which are essential for the removal of cytotoxic alkylation products, the premutagenic deamination product hypoxanthine and certain cyclic ethenoadducts such as ethenoadenine. In this paper, we have purified the Mag1 protein and characterized its substrate specificity. It appears...
Topics
- DNA Adducts
- DNA Glycosylases
- DNA Repair
- DNA-(Apurinic or Apyrimidinic Site) Lyase
- Endodeoxyribonucleases
- Methyl Methanesulfonate
- Multienzyme Complexes
- Mutagens
- Mutation
- Purines
- Recombination, Genetic
- Schizosaccharomyces
- Schizosaccharomyces pombe Proteins