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Article

Generation of a strong mutator phenotype in yeast by imbalanced base excision repair.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 1998

Glassner B J, Rasmussen L J, Najarian M T, Posnick L M, Samson L D

Abstract excerpt

Increased spontaneous mutation is associated with increased cancer risk. Here, by using a model system, we show that spontaneous mutation can be increased several hundred-fold by a simple imbalance between the first two enzymes involved in DNA base excision repair. The Saccharomyces cerevisiae MAG1 3-methyladenine (3MeA) DNA glycosylase, when expressed at high levels relative to the apurinic/apyrimidinic...

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Identifiers

PMID: 9707589
DOI: 10.1073/pnas.95.17.9997
PMCID: PMC21450

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REV1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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