Article
Generation of a strong mutator phenotype in yeast by imbalanced base excision repair.
Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 1998
Glassner B J, Rasmussen L J, Najarian M T, Posnick L M, Samson L D
Abstract excerpt
Increased spontaneous mutation is associated with increased cancer risk. Here, by using a model system, we show that spontaneous mutation can be increased several hundred-fold by a simple imbalance between the first two enzymes involved in DNA base excision repair. The Saccharomyces cerevisiae MA...
Topics
- Carbon-Oxygen Lyases
- DNA Glycosylases
- DNA Repair
- DNA-(Apurinic or Apyrimidinic Site) Lyase
- Deoxyribonuclease IV (Phage T4-Induced)
- Escherichia coli
- Escherichia coli Proteins
- Gene Expression
- Genes, Fungal
- Humans
- Methyl Methanesulfonate
- Mutagens
- Mutation
- N-Glycosyl Hydrolases
- Neoplasms
- Phenotype
- Saccharomyces cerevisiae