Article
Induction of S.cerevisiae MAG 3-methyladenine DNA glycosylase transcript levels in response to DNA damage.
Nucleic acids research - 11 Dec 1991
Chen J, Samson L
Abstract excerpt
We previously showed that the expression of the Saccharomyces cerevisiae MAG 3-methyladenine (3MeA) DNA glycosylase gene, like that of the E. coli alkA 3MeA DNA glycosylase gene, is induced by alkylating agents. Here we show that the MAG induction mechanism differs from that of alkA, at least in part, because MAG mRNA levels are not only induced by alkylating agents but also by UV light and the UV-mimetic agent...
Topics
- Blotting, Northern
- Cell Cycle
- Cycloheximide
- DNA Damage
- DNA Glycosylases
- DNA Repair
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Fungal
- Kinetics
- Methyl Methanesulfonate
- Mutation