Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B Study.

doi:10.1200/JCO.2008.17.5554

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Article

Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B Study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Nov 2008

Marcucci Guido, Maharry Kati, Radmacher Michael D, Mrózek Krzysztof, Vukosavljevic Tamara, Paschka Peter, Whitman Susan P, Langer Christian, Baldus Claudia D, Liu Chang-Gong, Ruppert Amy S, Powell Bayard L, Carroll Andrew J, Caligiuri Michael A, Kolitz Jonathan E, Larson Richard A, Bloomfield Clara D

Abstract excerpt

PURPOSE: To evaluate the prognostic significance of CEBPA mutations in the context of established molecular markers in cytogenetically normal (CN) acute myeloid leukemia (AML) and gain biologic insights into leukemogenesis of the CN-AML molecular high-risk subset (FLT3 internal tandem duplication [ITD] positive and/or NPM1 wild type) that has a significantly higher incidence of CEBPA mutations than the molecular...

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Identifiers

PMID: 18809607
DOI: 10.1200/JCO.2008.17.5554
PMCID: PMC2652095

Genes

FLT3
NPM1
BAALC
EPOR
ERG
GATA1
ZFPM1

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