Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis.

Blood - 12 Jul 2012

Pan Weijun, Pham Van N, Stratman Amber N, Castranova Daniel, Kamei Makoto, Kidd Kameha R, Lo Brigid D, Shaw Kenna M, Torres-Vazquez Jesus, Mikelis Constantinos M, Gutkind J Silvio, Davis George E, Weinstein Brant M

Abstract excerpt

Understanding the mechanisms that regulate angiogenesis and translating these into effective therapies are of enormous scientific and clinical interests. In this report, we demonstrate the central role of CDP-diacylglycerol synthetase (CDS) in the regulation of VEGFA signaling and angiogenesis. CDS activity maintains phosphoinositide 4,5 bisphosphate (PIP2) availability through resynthesis of phosphoinositides,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Blood Vessels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neovascularization, Physiologic

Share to Phosphatidylinositols

Share to RNA, Small Interfering

Share to Vascular Endothelial Growth Factor A

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22649102
DOI: 10.1182/blood-2012-02-408328
PMCID: PMC3398756

Genes

CDS2
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis.PMID 22649102Read ↗

Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recyclingSemantic proximity Read ↗

Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.Semantic proximity Read ↗

Zebrafish G protein gamma2 is required for VEGF signaling during angiogenesis.Semantic proximity Read ↗

AIBP Limits Angiogenesis Through γ-Secretase-Mediated Upregulation of Notch SignalingSemantic proximity Read ↗

Vegfd modulates both angiogenesis and lymphangiogenesis during zebrafish embryonic developmentSemantic proximity Read ↗

A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development.Semantic proximity Read ↗

Phosphatidylinositol Cycle Disruption is Central to Atypical Hemolytic-Uremic Syndrome Caused by Diacylglycerol Kinase Epsilon DeficiencySemantic proximity Read ↗

Mycn regulates vascular development through PI3K signaling pathway in zebrafishSemantic proximity Read ↗

Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in miceSemantic proximity Read ↗

Reverse genetics screen in zebrafish identifies a role of miR-142a-3p in vascular development and integrity.Semantic proximity Read ↗

Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning.Semantic proximity Read ↗

Regulation of Vegf signaling by natural and synthetic ligands.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.