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Article

Genome-wide patterns of intrahuman dengue virus diversity reveal associations with viral phylogenetic clade and interhost diversity.

Journal of virology - 1 Aug 2012

Parameswaran Poornima, Charlebois Patrick, Tellez Yolanda, Nunez Andrea, Ryan Elizabeth M, Malboeuf Christine M, Levin Joshua Z, Lennon Niall J, Balmaseda Angel, Harris Eva, Henn Matthew R

Abstract excerpt

Analogous to observations in RNA viruses such as human immunodeficiency virus, genetic variation associated with intrahost dengue virus (DENV) populations has been postulated to influence viral fitness and disease pathogenesis. Previous attempts to investigate intrahost genetic variation in DENV characterized only a few viral genes or a limited number of full-length genomes. We developed a whole-genome...

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Identifiers

PMID: 22647702
DOI: 10.1128/JVI.00736-12
PMCID: PMC3421746

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