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Article

Effect of DNMT3A R882H Hot Spot Mutations on DDX43 Promoter Methylation in Acute Myeloid Leukemia.

BioMed research international - 1 Jan 2024

Tabatabaei Tahere, Rezvany Mohammad Reza, Ghasemi Bahare, Vafaei Farzane, Zadeh Masoumeh Kiani, Zaker Farhad, Salmaninejad Arash

Abstract excerpt

Epigenetic alterations have been observed in many hematological malignancies, including acute myeloid leukemia (AML). Many of these alterations result from mutations in DNA methyl transferase (DNMT) enzymes, disabling them to methylate target genes in a proper way. In this case-control study, we investigated the association between R882H mutation in DNMT3A gene and DDX43 gene methylation in patients with AML. 47...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38807916
DOI: 10.1155/2024/9625043
PMCID: PMC11132831

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