Article
Comparison of High-Resolution Melting (HRM) Analysis with Direct Sequencing for the Detection of DNMT3A Mutations in AML Patients.
Asian Pacific journal of cancer prevention : APJCP - 1 Jul 2022
Moonesi Mohammadreza, Zaka Khosravi Saeed, Moradabadi Alireza, Rajaeinejad Mohsen, Heidari Mohammad Foad, Mahjub Golnoosh, Noroozi-Aghideh Ali
Abstract excerpt
OBJECTIVE: Acute myeloid leukemia (AML) is caused by abnormal gene expression following mutations. Many of the mutations in AML lead to gene instability and poor response to treatment. Among these mutations, DNMT3A mutation is exceedingly important due to its major role in methylation and its effect on the expression of other genes. Aberrant methylation due to DNMT3A mutations that mostly occur in exon 23,...
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