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Article

The hypoxic microenvironment upgrades stem-like properties of ovarian cancer cells.

BMC cancer - 29 May 2012

Liang Dongming, Ma Yuanyuan, Liu Jian, Trope Claes Goran, Holm Ruth, Nesland Jahn M, Suo Zhenhe

Abstract excerpt

BACKGROUND: To study whether hypoxia influences the stem-like properties of ovarian cancer cells and their biological behavior under hypoxia. METHOD: Ovarian cancer cell lines ES-2 and OVCAR-3 were cultivated in different oxygen tensions for proliferation, cell cycling and invasion analyses. The clonogenic potential of cells was examined by colony formation and sphere formation assays. Stem cell surface markers,...

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Identifiers

PMID: 22642602
DOI: 10.1186/1471-2407-12-201
PMCID: PMC3407800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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