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Stemness and chemoresistance are imparted to the OC cells through TGFβ1 driven EMT

14 Mar 2018

Abstract excerpt

Ovarian cancer (OC) is the fourth most common gynecological malignancy due to its highly aggressive, recurrent, and drug-resistant nature. The last two features are rendered by the presence of cancer stem cells (CSCs). Factors like TGFβ1 and their downstream signaling pathways are upregulated in most cancers and are known to induce EMT and stemness, but the exact mechanisms underlying the process remain...

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PMID: 29537103
DOI: 10.1002/jcb.26753

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