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Article

Multi-drug resistance 1 polymorphism is associated with reduced risk of gastric cancer in the Japanese population.

Journal of gastroenterology and hepatology - 1 Oct 2007

Tahara Tomomitsu, Arisawa Tomiyasu, Shibata Tomoyuki, Hirata Ichiro, Nakano Hiroshi

Abstract excerpt

BACKGROUND AND AIMS: Host genetic factors play a key role in gastric carcinogenesis, but the mechanism has not been clarified. The multi-drug resistance 1 (MDR1) gene mediates the expression of P-glycoprotein, which has a role in active transport of various substrates, including xenobiotics, and thus has a protective function in various tissues and organs like gastrointestinal epithelial cells. C3435T...

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Identifiers

PMID: 17608636
DOI: 10.1111/j.1440-1746.2007.04848.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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