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Article

The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer.

Journal of the National Cancer Institute - 2 Mar 2011

Baker Ann-Marie, Cox Thomas R, Bird Demelza, Lang Georgina, Murray Graeme I, Sun Xiao-Feng, Southall Stacey M, Wilson Jon R, Erler Janine T

Abstract excerpt

BACKGROUND: Emerging evidence implicates lysyl oxidase (LOX), an extracellular matrix-modifying enzyme, in promoting metastasis of solid tumors. We investigated whether LOX plays an important role in the metastasis of colorectal cancer (CRC). METHODS: We analyzed LOX expression in a patient CRC tissue microarray consisting of normal colon mucosa (n = 49), primary (n = 510), and metastatic (n = 198) tissues. LOX...

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Source

Identifiers

PMID: 21282564
DOI: 10.1093/jnci/djq569

Genes

LOX
SRC

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The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer.PMID 21282564Read ↗

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