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Article

Molecular Mechanism Responsible for Fibronectin-controlled Alterations in Matrix Stiffness in Advanced Chronic Liver Fibrogenesis.

The Journal of biological chemistry - 1 Jan 2016

Iwasaki Ayumi, Sakai Keiko, Moriya Kei, Sasaki Takako, Keene Douglas R, Akhtar Riaz, Miyazono Takayoshi, Yasumura Satoshi, Watanabe Masatoshi, Morishita Shin, Sakai Takao

Abstract excerpt

Fibrosis is characterized by extracellular matrix (ECM) remodeling and stiffening. However, the functional contribution of tissue stiffening to noncancer pathogenesis remains largely unknown. Fibronectin (Fn) is an ECM glycoprotein substantially expressed during tissue repair. Here we show in advanced chronic liver fibrogenesis using a mouse model lacking Fn that, unexpectedly, Fn-null livers lead to more...

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Identifiers

PMID: 26553870
DOI: 10.1074/jbc.M115.691519
PMCID: PMC4697189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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