Article
Fibrostenotic Phenotype of Myofibroblasts in Crohn's Disease is Dependent on Tissue Stiffness and Reversed by LOX Inhibition.
Journal of Crohn's & colitis - 28 Jun 2018
de Bruyn Jessica R, van den Brink Gijs R, Steenkamer Jessica, Buskens Christianne J, Bemelman Willem A, Meisner Sander, Muncan Vanesa, Te Velde Anje A, D'Haens Geert R, Wildenberg Manon E
Abstract excerpt
BACKGROUND AND AIMS: Crohn's disease is a chronic inflammatory disorder of the intestine and often leads to fibrosis, characterized by excess extracellular matrix [ECM] deposition, increased tissue stiffness, and stricture formation. Here we evaluated the contribution of myofibroblast-ECM interactions to the development of intestinal fibrosis in Crohn's disease. METHODS: Matched primary human myofibroblasts were...
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