Article
Expression of NKG2D and CD107 in CD8(+) effector memory lymphocytes in Churg-Strauss syndrome.
Clinical and experimental rheumatology - 1 Jan 2000
Boita Monica, Rolla Giovanni, Mallone Roberto, Martinuzzi Emanuela, Heffler Enrico, Circosta Paola, Elia Angela Rita, Cignetti Alessandro, Caillat-Zucman Sophie, de Menthon Mathilde, Guida Giuseppe
Abstract excerpt
OBJECTIVES: Churg-Strauss syndrome (CSS) is a necrotising vasculitis of small vessels in which oligoclonally expanded TCR Vβ CD8+ effector memory T cells populations (TEM) may be involved in vasculitic damage. The aim of this study was to assess the functional role of CD8+ T cells in CSS patients by flow cytometry analysis of membrane expression of cytotoxic markers NKG2D and CD107a. METHODS: Immunostaining of...
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