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Article

Alterations in the phenotype of CMV-specific and total CD8+ T-cell populations in Wegener's granulomatosis.

Cellular immunology - 1 Jul 2003

Lamprecht Peter, Vargas Cuero Ana L, Muller Antje, Csernok Elena, Voswinkel Jan, Maass Matthias, Solbach Werner, Gross Wolfgang L, Klenerman Paul

Abstract excerpt

Wegener's granulomatosis (WG) is an autoimmune disease of as yet unknown etiology. To date it has remained obscure what causes WG or determines disease progression. Case reports suggest that viral infections such as cytomegalovirus (CMV) reactivation may contribute to disease flares. In this study we found a skewing of the phenotype of CMV-specific CD8+tet(ramer)+ T-cells in WG. A marked proportion of these cells...

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PMID: 14572795
DOI: 10.1016/j.cellimm.2003.08.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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