Article
Clonal CD8+ TCR-Vbeta expanded populations with effector memory phenotype in Churg Strauss syndrome.
Clinical immunology (Orlando, Fla.) - 1 Jul 2008
Guida Giuseppe, Vallario Antonella, Stella Stefania, Boita Monica, Circosta Paola, Mariani Sara, Prato Giuseppina, Heffler Enrico, Bergia Roberta, Sottile Antonino, Rolla Giovanni, Cignetti Alessandro
Abstract excerpt
Churg Strauss Syndrome (CSS) is a systemic vasculitis in which oligoclonal T cell expansions might be involved in the pathogenesis. Combined analysis of TCR-Vbeta expression profile by flow cytometry and of TCR gene rearrangement by heteroduplex PCR was used to detect and characterize T cell expansions in 8 CSS patients, 10 asthmatics and 42 healthy subjects. In all CSS patients one or two Vbeta families were...
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