Article

A CD57 <sup>+</sup> cytotoxic CD8 T cell subset associated with fibrotic lung disease in systemic sclerosis

2025-01-29

Abstract excerpt

Interstitial lung disease (ILD) is a major cause of morbidity and mortality in systemic sclerosis (SSc); however, the immunopathologic mechanisms driving lung disease in SSc are unclear. T cells have been implicated as a likely driver of lung injury in SSc. Here, we have evaluated T cells in blood and lungs of patients with SSc-ILD and identified a specific population of cytotoxic CD8 T cells that is expanded in S...

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Literature Corpus work: 03174ee2-f8ab-5ec1-992b-c7e056d6d43c
DOI: 10.1101/2025.01.27.635121

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