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Article

Identification of amino acids within the P2X2 receptor C-terminus that regulate desensitization.

The Journal of physiology - 1 Oct 1999

Smith F M, Humphrey P P, Murrell-Lagnado R D

Abstract excerpt

1. The ATP-activated P2X2(a) and P2X2(b) receptor splice variants, which differ only in their C-terminal sequences, desensitize at different rates. We used mutational analysis to investigate the involvement of the C-terminal region in receptor desensitization. Rat wild-type and mutant P2X2 receptors were expressed in Xenopus oocytes and currents were measured using the two-electrode voltage-clamp technique. 2....

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Identifiers

PMID: 10517803
DOI: 10.1111/j.1469-7793.1999.00091.x
PMCID: PMC2269553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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