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Article

Genetic variation in the β2-adrenocepter gene is associated with susceptibility to bacterial meningitis in adults.

PloS one - 1 Jan 2012

Adriani Kirsten S, Brouwer Matthijs C, Baas Frank, Zwinderman Aeilko H, van der Ende Arie, van de Beek Diederik

Abstract excerpt

Recently, the biased β2-adrenoceptor/β-arrestin pathway was shown to play a pivotal role in crossing of the blood brain barrier by Neisseria meningitidis. We hypothesized that genetic variation in the β2-adrenoceptor gene (ADRB2) may influence susceptibility to bacterial meningitis. In a prospective genetic association study we genotyped 542 patients with CSF culture proven community acquired bacterial meningitis...

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Share to Adrenergic beta-Antagonists
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Genetic Variation

Share to Meningitis, Meningococcal

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Share to Polymorphism, Single Nucleotide

Share to Receptors, Adrenergic, beta-2

Source

Open in PubMed Open full text

Identifiers

PMID: 22624056
DOI: 10.1371/journal.pone.0037618
PMCID: PMC3356289

Genes

ADRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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