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Article

The impact of ADRB2 polymorphisms on immune responses and norepinephrine-induced immunosuppression.

Journal of leukocyte biology - 10 Jan 2023

Stolk Roeland F, Bruse Niklas, Ter Horst Rob, Jansen Aron, Ricaño Ponce Isis, Gerretsen Jelle, van der Hoeven Johannes, Kumar Vinod, Netea Mihai G, Pickkers Peter, Kox Matthijs

Abstract excerpt

RATIONALE: To evaluate whether common nonsynonymous variants [single-nucleotide polymorphisms (SNPs) or SNP haplotypes] in the β2-adrenergic receptor render subjects more susceptible to norepinephrine-induced immunosuppression and whether they are associated with dysregulated ex vivo and in vivo inflammatory responses. METHODS: Peripheral blood mononuclear cells from healthy volunteers (main cohort: n = 106,...

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Share to Polymorphism, Single Nucleotide

Share to Receptors, Adrenergic, beta-2

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Identifiers

PMID: 36822159
DOI: 10.1093/jleuko/qiac005

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